By Jackson Rubem
Dengue fever vaccine will be possible soon, thanks to discovery of London researchers. They identified a class of antibodies able to combat four viral types that affect 400 million people every year throughout the world.
Dengue fever also known as breakbone fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases the disease develops into the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs, according Wikipedia.
During a dengue antibody study, scientists at Imperial College London found a group of antibodies that recognize a unique envelope dimer epitope (EDE), which spans two protein subunits on the viral surface. Antibodies to EDE effectively neutralized all four dengue serotypes in cell culture experiments.
The international team of researchers released the study on15 December in Nature Immunology. The discovery will make it possible to develop a dengue fever vaccine that protects widely against dengue. Despite the global dengue disease prevention, the virus transmitted by the mosquitos infects millions people per year,
“The shell of the virus is made up of a rather beautiful array of these envelope proteins all stacked together,” study co-author Gavin Screaton of Imperial College London said during a press briefing. “The antibody actually recognizes the junction between two of these proteins, so it will only recognize the protein when it’s made on the virus.”
The research of Imperial College has made the development of these antibodies a realistic goal toward a future dengue fever vaccine universal against disease. “The description herein of such antibodies and potent cross-reactivity (which protects against the four types viral) indicating a path to the development of subunit Vaccines containing the desired epitope and possible strategies To recap responses observed in natural infections sequential, “added the immunologist.
What is the treatment for dengue fever currently
Medicine for dengue fever is supportive, using either oral or intravenous rehydration for mild or moderate disease, and intravenous fluids and blood transfusion in more severe cases. The number of cases of dengue fever has Increased Dramatically since the 1960s, with between 50 and 528 million people infected yearly. Early descriptions of the condition date from 1779, and its viral cause and the transmission was Figured Out in the early 20th century. Dengue has been a global problem since the Second World War and is endemic in more than 110 countries. Apart Eliminating from the mosquitoes, work is ongoing on the vaccine, the well as medication targeted directly at the virus.
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